項目來源：中國科學院再生生物學重點實驗室
課題名稱：惡性腫瘤冷凍消融和介入治療前後腫瘤標誌物變化研究
申請者：邱大衛
所在單位：廣州復大腫瘤醫院
申請時間：2010年11月1日
研究內容和預期成果：
The presence of serum tumor markers, carbohydrate antigen 242 (CA242), carbohydrate antigen 199 (CA199), carbohydrate antigen 125 (CA125), carcinoembryonic antigen (CEA), tumorsupplied group of factors (TSGF) and tumor necrosis factor-a (TNF-a), is closely associated with invasion and metastasis of many malignancies. The expression of these markers were measured in serum taken from 37 pancreatic cancer patients prior to treatment. Levels of CA242, CA199, CA125, CEA and TNF-a expression correlated with tumor size, clinical stage, tumor differentiation, lymph node and liver metastasis (P�.05). One month after cryosurgery, serum levels of these markers were significantly reduced compared with levels prior to cryosurgery (P�.05), whereas there was no significant difference was found between serum levels before and after chemotherapy (P[0.05). Thus, cryosurgery is more effective than chemotherapy for decreasing CA242, CA199, CA125, CEA, TSGF and TNF-a serum levels in these patients.